CBSE - XI Science - Physics - Work, Energy and Power
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Energy conservation is always observed. No energy is lost, only it's converted into some other form.
So reframing the question as "Is it possible to have a collision in which the all the energy is converted into completely different energy form?"
Yes, a particle and it's antiparticle when collide, called annihilation, their masses are completely converted into radiation carrying equivalent energy.
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