How can a t-butyl substituent be used as a blocking group in aromatic electrophilic substitutions?
Asked by Topperlearning User
| 1st Jun, 2016,
02:54: PM
Expert Answer:
The Friedel-Crafts alkylation can be reversed, especially when a 3° alkyl group such as Me3C is present.
Dealkylation is affected with AlCl3 by transfer of Me3C+ to another arene, used as the solvent, or at high temperatures by protonation with H+ and loss of Me3C+as Me2C=CH2.
Me3C- , introduced into a ring, is used to block an active position and/or to direct another group into the ring , and then removed.
Answered by
| 1st Jun, 2016,
04:54: PM
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