How can you prepare primary, secondary and tertiary amine by reduction?

Asked by Topperlearning User | 4th Jul, 2014, 10:30: AM

Expert Answer:

Primary, secondary and tertiary amines can be prepared by reduction of the corresponding amides.

                                  LiAlH4/Ether
C6H5CONH+ 4[H] ---------------->  C6H5CH2NH2 + H2O     
 
For preparing secondary and tertiary amines we need to reduce the secondary and tertiary amides.
                            LiAlH4/Ether         
CH3CONHCH3  --------------->  CH3CH2NHCH3
   N-methyl acetamide                       Ethyl methyl amine 20
      
          CH3                                                     CH3
          |            LiAlH4/Ether                 |                       
CH3CON-CH3 ---------------->   CH3CH2N-CH3
N,N-Dimethylacetamide          Ethyl dimethyl amine 30
 

Answered by  | 4th Jul, 2014, 12:30: PM