CBSE Class 12-science Answered
What is the change in km and V max value in case of competitive and non competitive inhibition of enzymes
Asked by mayurakshighosh200 | 30 Nov, 2019, 10:52: AM
Expert Answer
1) In competitive inhibition, the Vmax does not change because increasing amounts of substrate can swamp the inhibitor (present in fixed concentration), allowing the enzyme to effectively not see the inhibitor at high substrate concentrations.
On the other hand, the apparent Km for competitive inhibition goes up because it takes more substrate to get the competitively inhibited reaction to Vmax/2.
2) In non-competitive inhibition, the Km does not change. This is because Km is a measure of the affinity of the enzyme for its substrate and this can only be measured by active enzyme.
The fixed amount of inactive enzyme in non-competitive inhibition does not affect the Km and the Km, therefore is unchanged.
Answered by Ramandeep | 02 Dec, 2019, 10:53: AM
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