NEET Class neet Answered
Describe the metabolic profile in the liver for untreated type 1 diabetes
Asked by noobgamer0528 | 21 Apr, 2021, 07:17: PM
Expert Answer
The liver is either storing glucose or releasing glucose in a normal healthy individual. One of the functions of pancreatic insulin is to inhibit hepatic glucose release, thereby keeping peripheral blood glucose levels under control. But the dominant effect of insulin on the liver is not inhibiting hepatic glucose production, it’s stimulating hepatic glucose storage or uptake at the time of the meal. In a healthy animal, that does not have diabetes, the liver is storing anywhere from 35 to 65 % of a total glucose load, at any given time. So the liver is actually an enormous storage facility, if you will, for all of the carbohydrate that a healthy individual eats. The failure to store glucose in the liver in both type 1 and type 2 diabetes is a huge problem therapeutically.
Answered by Sheetal Kolte | 23 Apr, 2021, 03:27: PM
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