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After attacking E.coli the lamda phase first transcribe for nuclease which degrades the host DNA but phase DNA is not affect by nuclease because? 

Asked by amitjena226 30th November 2017, 12:47 PM
Answered by Expert

The lambda phage (T4) genes encode enzymes called nucleases that degrade the host DNA. However, in this process, the phage DNA is not destroyed. This is because the T4 DNA contains an unusual base – 5-hydroxymethylcytosine (HMC, cytosine with a –CH2OH group attached to one of the atoms in the cytosine molecule) instead of the normal cytosine. In addition, derivatives of glucose molecules are attached to the HMC. These modifications protect T4 DNA from degradation by the nucleases that it uses to degrade the DNA of the host cell.

Answered by Expert 1st December 2017, 11:23 AM
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