Question
Sun March 15, 2015 By: Areeba Ahmad

What is RFLP and what is its work?

Expert Reply
Sivanand Patnaik
Mon March 16, 2015

Restriction Fragment Length Polymorphism (RFLP) is a difference in homologous DNA sequences that can be detected by the presence of fragments of different lengths after digestion of the DNA samples with specific restriction endonucleases. RFLP, as a molecular marker, is specific to a single clone/restriction enzyme combination.

The RFLP probes are frequently used in genome mapping and also finds use in genotyping, forensics, paternity tests, hereditary disease diagnostics, etc.

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