Question
Sat April 17, 2010 By: Somya Pandey

Pepsinogen is secreted in the stomach...

Expert Reply
Sun April 18, 2010

In the stomach, chief cells release pepsinogen, which is activated by HCl released from parietal cells in the stomach lining. The hormone gastrin and the vagus nerve trigger the release of both pepsinogen and HCl from the stomach lining when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin (the active form).

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