Question
Thu September 03, 2009 By:

How golgi body produces lysosome and perixosome

Expert Reply
Tue September 08, 2009

Lysosomes are roughly spherical bodies bounded by a single membrane. They are manufactured by the Golgi apparatus. Proteins glycosylated with residues of mannose-6-phosphate will leave the Golgi in transport vesicles that eventually fuse with lysosomes.

The Golgi complex sorts the lysosomal enzyme in the Trans region. It is received from the rough endoplasmic reticulum in the cis region. There it has a phosphate radical attached to the mannose residue. This mannose-6 phosphate forms a sorting signal that moves through the cisternae to the trans region where it binds to a specific receptor. After it binds to the receptor, it begins to bud and a coat made of clathrin forms around the bud (to strengthen it). It moves away to fuse with a developing lysosome. This lysosome contains a hydrogen ion pump on its surface. The pump works to acidify the environment inside the lysosome.


Peroxisomes are organelles that contain oxidative enzymes, such as D-amino acid oxidase, ureate oxidase, and catalase. They may resemble a lysosome, however, they are not formed in the Golgi complex.

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