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why peptide hormones require extracellular receptors and steroid hormones do not ?

Asked by निकोदिमुस 24th November 2017, 10:15 PM
Answered by Expert
Peptide hormones show characteristics of cell surface receptors that are built into the plasma membrane. It has has charges on it so therefore cannot cross the lipid bilayer by itself and therefore needs to bind to the receptor on the cell membrane and initiate cell signalling by receiving extracellular molecules. Example- Insulin
But steroid hormones receptors are found inside the cytoplasm and are referred to as intracellular or nuclear receptors.They cross the lipid bilayer because it is hydrophobic. Example- Testosterone
Answered by Expert 25th November 2017, 11:51 AM
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