CBSE Class 12-science Answered
Expert Answer
(i) Difference between Mendelian disorder and chromosomal disorder
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Mendelian disorder |
Chromosomal disorder |
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1. This disorder is mainly due to alteration or mutation in a single gene. |
1. This disorder is caused due to absence or excess or abnormal arrangement of one or more chromosomes. |
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2. It follows Mendel's principles of inheritance. |
2. It does not follow Mendel's principles of inheritance. |
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3. It may be recessive or dominant in nature. |
3. It is always dominant in nature. |
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4. Examples: Haemophilia, sickle-cell anaemia |
4. Example: Turner's syndrome |
(ii) Two chromosomal aberration-associated disorders are Down's syndrome and Klinefelter's syndrome.
(iii) (a) Down's syndrome: The individuals have overall masculine development, but they express feminine characteristics such as development of breasts, i.e. gynaecomastia. They are sterile.
(b) Klinefelter's syndrome: The females are sterile as ovaries are rudimentary. Other secondary sexual characters are also lacking.
Concept Videos
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Principles of Inheritance and Variation
Principles of Inheritance and Variation, Mutations and Genetic Disorders -
Principles of Inheritance and Variation
Principles of Inheritance and Variation, Mutations and Genetic Disorders -
Pedigree Analysis
This video talks about pedigree analysis and its importance -
Mutations
This video talks about mutations and its types
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