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CBSE Class 12-science Answered

Autoimmune diseases are different from immunodeficiency diseases. How? Give one example of each in humans.
Asked by sunil2791 | 06 Feb, 2018, 02:08: PM
answered-by-expert Expert Answer

Differences between autoimmune and immunodeficiency diseases:

Characteristics

Autoimmune diseases

Immunodeficiency diseases

Cause  

Caused by an overactive immune system in the absence of a pathogen

Caused by an insufficient immune response in the presence of a pathogen or opportunistic organism

Age

Common in middle age people

Age distribution varies depending on the underlying cause.

Sex

Common among females

No specific sex distribution

Course

Has a remitting and relapsing course

Static and may increase in severity with time

Etiology

Multifactorial

Caused by a specific genetic defect or environmental cause

Diagnosis

Diagnosed by immune biomarkers which detect typical associations of symptoms and signs

Diagnosed by detecting the missing component of the immune system by specific laboratory assays

Treatment

Treated with immune suppressants

Treated by replacing the missing component with transfusions, prevention of infections with immunization and prophylaxis or in selected cases with stem cell transplantation

Examples

Graves’ disease

Severe combined immunodeficiency (SCID)

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