Why meristemetic tissue cells have small or no vacuole because  all plant cells have large vacuole? 

The function of meristematic cells is to multiply and divide at a higher rate in order to give rise to new plant cells. These cells keep on dividing, hence the nutrients available in the cells are utilised fast. There is no requirement for the provision of storage of nutrients in these cells. The function of vacuoles is to store excess nutrients and salts. Its presence in highly multiplying cells does not serve the purpose. In addition to this all diving cells require dense cytoplasm to increase the efficiency the cell division. Hence, we can say it is an adaptation in meristematic cells to serve the function of mitosis and ensure growth in plants.