Why do the inner membrane of mitochondria have more carrier proteins than outer membrane?

Asked by pb_ckt | 2nd May, 2019, 09:51: PM

Expert Answer:

  • Most of the energy derived from oxidative metabolism is produced by the process of oxidative phosphorylation which takes place in the inner mitochondrial membrane.
  • The high-energy electrons from NADH and FADH2 are transferred through a series of carriers in the inner membrane to molecular oxygen.
  • The energy derived from these electron transfer reactions is converted to potential energy stored in a proton gradient across the membrane, which is then used to drive ATP synthesis.
  • The inner mitochondrial membrane represents the principal site of ATP generation, and this critical role is reflected in its structure.
  • First, its surface area is substantially increased by its folding into cristae. In addition, the inner mitochondrial membrane contains an unusually high percentage (greater than 70%) of proteins, which are involved in oxidative phosphorylation as well as in the transport of metabolites.
  • In the inner mitochondrial membrane, the protein-to-lipid ratio is 80:20, in contrast to the outer membrane, which is 50:50.

Answered by Sheetal Kolte | 3rd May, 2019, 02:17: PM