what is mean by Nef carbonyl reaction?

Asked by  | 3rd Apr, 2013, 09:24: PM

Expert Answer:

The conversion of nitro compounds into carbonyls is known as the Nef Reaction. 

Mechanism of the Nef Reaction:

Nitroalkanes being relatively strong carbon acids, undergoes deprotonation to form the nitronate salt. Then hydrolysis of this intermediate takes place in a strong acid to give the carbonyl compound. The hydrolysis is done in strong acid to prevent the formation of side products such as oximes or hydroxynitroso compounds.

Answered by  | 4th Apr, 2013, 10:37: AM

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