what is mean by Nef carbonyl reaction?
Asked by | 3rd Apr, 2013, 09:24: PM
Expert Answer:
The conversion of nitro compounds into carbonyls is known as the Nef Reaction.
Mechanism of the Nef Reaction:
Nitroalkanes being relatively strong carbon acids, undergoes deprotonation to form the nitronate salt. Then hydrolysis of this intermediate takes place in a strong acid to give the carbonyl compound. The hydrolysis is done in strong acid to prevent the formation of side products such as oximes or hydroxynitroso compounds.
Mechanism of the Nef Reaction:
Nitroalkanes being relatively strong carbon acids, undergoes deprotonation to form the nitronate salt. Then hydrolysis of this intermediate takes place in a strong acid to give the carbonyl compound. The hydrolysis is done in strong acid to prevent the formation of side products such as oximes or hydroxynitroso compounds.
Answered by | 4th Apr, 2013, 10:37: AM
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