Please Explain Translocation.

Asked by padminik | 24th Mar, 2009, 04:52: PM

Expert Answer:

Translocations are chromosomal abnormalities which occur when chromosomes break and the fragments rejoin to other chromosomes. There are many structurally different types of translocations. There is no loss of genetic material, although the breakpoint can cause disruption of a critical gene or juxtapose pieces of two genes to create a fusion gene that induces cancer.  In general however, the problem with translocations occurs during meiosis and is manifest as reductions in fertility.

Answered by  | 25th Mar, 2009, 11:12: AM

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