Question
Tue February 19, 2013 By:

GABRIEL phthalimide synthesis is preffered for synthesising primary amines.WHY

Expert Reply
Tue February 19, 2013

Preparation of Amines

The alkylation of ammonia, Gabriel synthesis, reduction of nitriles, reduction of amides, reduction of nitrocompounds, and reductive amination of aldehydes and ketones are methods commonly used for preparing amines.

Alkylation of ammonia

The reaction of ammonia with an alkyl halide leads to the formation of a primary amine. The primary amine that is formed can also react with the alkyl halide, which leads to a disubstituted amine that can further react to form a trisubstituted amine. Therefore, the alkylation of ammonia leads to a mixture of products.

The utility of Gabriel phthalimide synthesis is based on the fact that the alkylation of ammonia is an unselective and inefficient route to amines in the laboratory on an industrial scale, the alkylation of ammonia is, however, widely employed.
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